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Nous assistons actuellement à une pression redoublée des partisans de la légalisation du cannabis qui s’exerce sur tous les médias. Les lobbyistes sont actionné leurs réseaux intérieur pour mener ce combat.
Il convient de rappeler ce qu’est le cannabis et quels ravages il provoque sur la santé de nos concitoyens, tout particulièrement chez les adolescents. Chez ces jeunes, dont le cerveau est en cours de maturation, le cannabis produit des effets particulièrement néfastes, souvent irréversibles. De nombreux troubles physiques et psychiques sont observés, pouvant mener à la schizophrénie. Le mécanisme d’action du cannabis est bien connu: la substance psychotrope, le tétrahydrocannabinol (THC) est très soluble dans les lipides et, de ce fait se fixe aux membranes cellulaires. Il franchit aisément la barrière hémato-encéphalique et s’accumule dans le cerveau. Il y persiste très longtemps: le THC d’un seul joint demeure plus d’une semaine dans cet organe. Son élimination dans les urines dure huit semaines. Après plusieurs joints, cela peut durer au moins deux mois. Au niveau du cerveau, il provoque de nombreux troubles: perturbation de la mémoire, défocalisation de l’attention, incoordination motrice, désinhibition conduisant à des prises de risques, potentialisation des effets ébriants ou hallucinogènes, schizophrénie, anxiété et dépression. Les enseignants constatent que les élèves ont des difficultés à ordonner leurs pensées et manquent d’attention pendant les cours. La situation s’est encore aggravée avec l’augmentation constante de la concentration en THC dans les cannabis vendus actuellement: il y a cinquante ans, le joint contenait 2 à 3 % de THC alors qu’aujourd’hui le taux peut atteindre 40 % et devient plus puissant qu’un rail de cocaïne. Un des dangers du cannabis est que son addiction conduit souvent vers la recherche de drogues plus dures, comme la cocaïne. On estime que 10 à 20 % des patients passent à une consommation plus forte et deviennent accros au crack. Le cannabis seul est responsable de 300 morts de la route et les risques d’accidents mortels sont 14 fois plus élevés lorsque l’alcool est associé.
Un des arguments des partisans de la légalisation est de prétendre qu’un contrôle pourra être exercé sur la qualité du cannabis produit légalement, en particulier sa teneur en THC. La porosité de nos frontières, l’instabilité des pays qui nous entourent risquent de faire de notre une plaque tournante de la drogue.
Un autre argument invoqué est l’inefficacité de la répression, telle qu’elle est pratiquée . En vérité, ceci n’est pas fondé. La criminalisation des drogue par la loi Abdou Natif Gueye ,très dissuasive à permis d’amoindrir les dégâts médicaux et sociaux.
Le cannabis, un médicament?
Enfin, certains justifient cette campagne pour la légalisation par la présence de vertus thérapeutiques chez le cannabis et n’hésitent pas à parler de «médicament». Or, en l’état actuel, le cannabis ne répond pas à la définition d’un médicament. À ce stade, il convient de rappeler ce qu’est un médicament et les étapes successives qu’il doit traverser avant d’être mis sur le marché. Un médicament est une molécule possédant des propriétés préventives ou curatives à l’égard des maladies humaines et animales, susceptible de restaurer, corriger ou modifier leurs fonctions organiques. De la découverte de la molécule à l’autorisation à l’Autorisation de Mise sur le Marché (AMM), un médicament doit franchir avec succès différentes phases, s’étalant sur environ dix ans: phase de recherche et développement, étude de toxicologie, recherche clinique – cette dernière comprenant elle-même une phase 1 (étude de la tolérance), une phase 2 (étude de l’efficacité), une phase 3 (essai comparatif), et une phase 4 (administrative). La mise au point d’une nouvelle spécialité coûte environ 800 millions d’euros. Enfin, pour que le médicament obtienne l’AMM, il doit présenter un bon rapport bénéfices/risques.
Environ 75 types de cannabinoïdes ont été identifiés dans la plante, parmi lesquels le THC (Térahydrocannabinol) et le CBD (Cannabidiol) sont les plus documentés. À ce jour, aucun de ces composés d’origine végétale n’a fait l’objet d’un protocole d’étude en vue d’une AMM et donc aucun ne peut être qualifié de médicament. Néanmoins, se basant sur les effets biologiques évidents du THC, certains prétendent utiliser la plante cannabis elle-même. Or, la composition en THC et autres composés est extrêmement variable suivant le plant. Cette variabilité s’oppose à la conception que l’on a d’un médicament, qui doit être une substance pure, agissant à des doses déterminées. De plus, jusqu’à présent, étant donné l’insolubilité du THC, traiter des patients en leur faisant fumer soit la plante elle-même, soit sa résine, reste une méthode peu contrôlable, tant le passage des principes à l’organisme est aléatoire. Enfin, le THC étant essentiellement soluble dans les lipides, sa rémanence et son élimination sont des paramètres difficiles à appréhender: encore une difficulté qui s’oppose à la notion de médicament
Comme on le voit, seule une substance issue du cannabis et ayant obtenu une AMM pourrait être qualifiée de «médicament», comme ce fut le cas pour bon nombre de molécules d’origine végétale présentes aujourd’hui dans notre pharmacopée. Ceci n’exclut pas que les recherches puissent se poursuivre pour mieux connaître les mécanismes d’action du cannabis. Pour autant, nul individu responsable ne devrait en conscience utiliser l’argument du «médicament» pour justifier sa légalisation.
Il nous faut sauver nos enfants du cannabis avant qu’il ne soit trop tard. Pour cela il faut que les pouvoirs publics prennent conscience qu’il est indispensable d’appliquer réellement notre arsenal répressif, mais également de mettre en place un plan de prévention destiné à informer nos jeunes élèves, dès l’école primaire, sur les dangers de cette drogue. l’expérience vécue par les pays qui ont légalisé le cannabis doit nous inciter à refuser cette éventualité dans notre pays. La logique financière et économique ne doit plus primer sur la santé de notre société. Introduire la légalisation du cannabis serait synonyme d’une catastrophe sanitaire dont nos pouvoirs publics porteraient une lourde responsabilité devant l’histoire et nos générations futures.
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